Precautions and Warnings With Acyclovir and Hydrocortisone

If you get infections easily, tell your healthcare provider before starting treatment with acyclovir and hydrocortisone. Other warnings and precautions apply to women who are pregnant or breastfeeding, and people who are allergic to any of the ingredients used to make this drug. In addition, keep in mind that this drug is only intended for use on the lips or the skin around the mouth.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to using acyclovir and hydrocortisone (Xerese™) if you have:
  • A weakened immune system, or get infections easily
  • Any allergies, including to medications, foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
You should also tell your healthcare provider about any other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Acyclovir and Hydrocortisone Precautions and Warnings

Some warnings and precautions to be aware of with this drug include the following:
  • This medication should only be used on the lips or the skin around the mouth. Do not use it in the mouth, nose, or eyes, or on the genitals. Acyclovir and hydrocortisone should not be used to treat genital herpes.
  • Acyclovir and hydrocortisone works best when started at the first signs of a cold sore. Try to use the medication at the earliest signs of an outbreak.
  • Do not put a bandage or other dressing over your cold sore while using acyclovir and hydrocortisone. Doing so may increase your risk for skin irritation.
  • There are other skin infections that may resemble a cold sore. Acyclovir and hydrocortisone will not work to treat these other infections. Therefore, contact your healthcare provider if your cold sore has not healed within two weeks -- it may be something else.
  • Acyclovir and hydrocortisone is unlikely to react with other medications (see Acyclovir and Hydrocortisone Drug Interactions).
  • Acyclovir and hydrocortisone is a pregnancy Category B medication, which means it is probably safe for use during pregnancy. Talk to your healthcare provider about the risks and benefits of using this medication while pregnant (see Xerese and Pregnancy for more information).
  • Acyclovir and hydrocortisone is unlikely to pass through breast milk. Even so, if you are breastfeeding a child, talk with your healthcare provider (or your child's healthcare provider) before using it (see Xerese and Breastfeeding).

Acyclovir and Hydrocortisone Information

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