Drug Interactions With Tesamorelin

Although there are no clear tesamorelin drug interactions at this time, this does not mean the medication could not react with other products and vice versa. People taking corticosteroids, for example, may need their doses adjusted when taking tesamorelin, and medicines metabolized by the liver could cause problems.

An Overview of Tesamorelin Interactions

It is not yet clear how (or even if) tesamorelin acetate (Egrifta™) may react with other drugs. However, the medication may, at least theoretically, affect how the body breaks down (metabolizes) certain other drugs.
Many medications are metabolized by enzymes in the liver. One study showed that tesamorelin did not have a significant effect on CYP 3A4 enzymes (CYP 3A4 is one of the enzymes that metabolizes several medications). However, there are several different types of liver enzymes, and it is unknown if tesamorelin might affect any of those.
Tesamorelin works by causing the body to produce more growth hormone. Previous research suggests that changes in growth hormone may have an influence on liver enzymes, perhaps changing the way the liver metabolizes medications. Therefore, it is wise for your healthcare provider to carefully monitor your medications in terms of their effectiveness and side effects when you start or stop taking tesamorelin.
Increased growth hormone production in the body can decrease cortisol levels. People being treated for adrenal insufficiency may need increased glucocorticoid doses after beginning tesamorelin treatment. This interaction is most likely to occur in people taking cortisone or prednisone.
It is possible that not all drug interactions with tesamorelin were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific interactions that may apply to you.

Tesamorelin Drug Information

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