What Is Tesamorelin Used For?

HIV medications can cause an excess accumulation of fat around the abdomen; however, this side effect can be managed with tesamorelin. The drug is used once a day and is injected subcutaneously in the stomach area. It is not approved for use in older adults, children, or people with compromised kidney or liver function because it has not been adequately studied in these groups.

An Overview of Uses for Tesamorelin

Tesamorelin acetate (Egrifta™) is an injectable medication approved to diminish excess abdominal body fat in people who have a condition called lipodystrophy as a result of the medicine they take for human immunodeficiency virus (HIV).
 
Lipodystrophy is a change in the way the body produces, uses, and stores fat. With this condition, fat often decreases in certain areas, especially the face, arms, legs, and buttocks. Also, fat can be built up in some areas, especially the stomach, breasts, and back of the neck. HIV medicines that are known to cause lipodystrophy are the protease inhibitors (PIs) and the nucleoside reverse transcriptase inhibitors (NRTIs).
 
As previously stated, tesamorelin is approved to reduce abdominal fat (stomach fat) in people with lipodystrophy due to HIV medications. Thus, the effectiveness of tesamorelin can be seen by measuring the distance around a person's waist. This medication is not approved for weight loss and will not cause weight loss.
 

How Does Tesamorelin Work?

Tesamorelin contains a human growth hormone-releasing factor (GRF), also known as growth hormone-releasing hormone (GHRH). In humans, this hormone is produced in the brain and acts to increase the production and release of growth hormone (GH).
 
Growth hormone is known to have both anabolic (building up of organ tissues) and lypolytic (breakdown of fatty tissue) effects. Though the effects of GH are extensive, the action of fat breakdown is believed to be responsible for the reduction in fatty tissue in the stomach.
 

Tesamorelin Drug Information

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